呼吸器センター内科
このページを印刷
このページを印刷
肺がんの診療は、診断から治療および緩和ケアまで、患者さんに安心して受診していただけるように、一貫して行っています。当院では、病理部で肺がん細胞のEGFR遺伝子変異などを検査しており、個々の患者さんに適したお薬(分子標的薬)を選択し、個別化治療を行っています。また、肺がんの治療成績向上のため、多くの臨床試験に参加し、新しい治療法の開発にも取り組んでいます。
間質性肺炎やびまん性汎細気管支炎などのびまん性肺疾患に関しては、厚生労働省のびまん性肺疾患に関する調査研究班に参加し、診断や治療に関する研究を行っています。
細菌性肺炎、肺結核、非結核性抗酸菌症、肺アスペルギルス症など、種々の原因菌による呼吸器感染症を速やかに診断し、適切に治療しています。
|
2019年度 |
2020年度 |
2021年度 |
2022年度 |
2023年度 |
---|---|---|---|---|---|
原発性肺癌 |
438 |
386 |
411 |
361 |
410 |
肺炎 |
221 |
163 |
123 |
95 |
146 |
COVID2019感染症 |
- |
27 |
185 |
187 |
81 |
びまん性汎細気管支炎 |
12 |
10 |
7 |
8 |
1 |
気管支拡張症 |
6 |
4 |
6 |
9 |
18 |
胸膜炎/膿胸 |
23 |
23 |
21 |
21 |
18 |
肺真菌症 |
17 |
21 |
9 |
11 |
17 |
肺結核 |
21 |
20 |
26 |
24 |
12 |
非結核性抗酸菌症 |
50 |
59 |
44 |
51 |
86 |
間質性肺炎 |
137 |
161 |
143 |
182 |
185 |
器質化肺炎 |
9 |
6 |
9 |
8 |
1 |
好酸球性肺炎 |
6 |
6 |
4 |
6 |
7 |
慢性閉塞性肺疾患 |
34 |
14 |
13 |
22 |
22 |
気管支喘息 |
39 |
22 |
6 |
11 |
19 |
気胸/縦隔気腫 |
9 |
12 |
10 |
15 |
21 |
サルコイドーシス |
15 |
9 |
12 |
10 |
16 |
その他腫瘍 |
- |
42 |
23 |
38 |
31 |
希少疾患 |
- |
7 |
4 |
6 |
6 |
その他 |
175 |
35 |
47 |
34 |
16 |
合計 |
1212 |
1027 |
1103 |
1099 |
1121 |
|
2019年度 |
2020年度 |
2021年度 |
2022年度 |
2023年度 |
---|---|---|---|---|---|
気管支鏡件数 |
282 |
226 |
282 |
289 |
384 |
CTガイド下生検数 |
32 |
9 |
18 |
7 |
5 |
Ando T*, Kage H, Matsumoto Y, Zokumasu K, Yotsumoto T, Maemura K, Amano Y, Watanabe K, Nakajima J, Nagase T, Takai D: Integrin α11 in non-small cell lung cancer is associated with tumor progression and postoperative recurrence. Cancer 111(1):200-208,2020
*The University of Tokyo
Mikami Y*, Jo T, Matsuzaki H, Ishimori T, Saito M, Sakamoto Y, Yamauchi Y, Takai D, Yatomi Y, Nagase T: Preoperative intervention with long-acting bronchodilators for the reduction of postoperative pulmonary complications in untreated patients with obstructive lung disease. Clin Respir J. 14(2):92-101,2020
*The University of Tokyo
Tashiro M*, Takazono T, Saijo T, Yamamoto K, Imamura Y, Miyazaki T, Kakeya H, Ando T, Ogawa K, Kishi K, Tokimatsu I, Hayashi Y, Fujiuchi S, Yanagihara K, Miyazaki Y, Ichihara K, Mukae H, Kohno S, Izumikawa K: Selection of oral antifungals for initial maintenance therapy in chronic pulmonary aspergillosis: A longitudinal analysis. Clin Infect Dis. 70(5):835-42,2020
*Nagasaki University Graduate School of Biomedical Sciences
Uruga H, Fujii T, Nakamura N, Moriguchi S, Kishi K, Takaya H: Squamous cell transformation as a mechanism of acquired resistance to tyrosine kinase inhibitor in EGFR-mutated lung adenocarcinoma: a report of two cases. Respirol Case Rep. 8(2):e00521,2020
Tateishi K*, Ko R, Shukuya T, Okuma Y, Watanabe S, Kuyama S, Murase K, Tsukita Y, Ashinuma H, Nakagawa T, Uematsu K, Nakao M, Mori Y, Kaira K, Mouri A, Miyabayashi T, Sakashita H, Matsumoto Y, Tanigawa T, Koizumi T, Morita S, Kobayashi K, Nukiwa T, Takahashi K: Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study. Oncologist. 25(4):e668-e674,2020
*Shinshu University School of Medicine
Kasai T*, Mori K, Kishi K, Kaburagi T, Hosomi Y, Imai H, Yamada Y, Yomota M, Moriguchi S, Seike M, Minato K, Gemma A: A phase I and extension study of S-1 and carboplatin for previously untreated patients aged 75 years or more with advanced non-small cell lung cancer -TCOG 1101. Int J Clin Oncol. 25(5):867-875,2020
*Tochigi Cancer Center
Ogawa K, Uruga H, Fujii T, Fujimori S, Kohno T, Kurosaki A, Kishi K, Abe S: Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia. BMC Pulm Med. 20(1):307,2020
Takada K, Miyamoto A, Nakahama H, Moriguchi S, Takahashi Y, Ogawa K, Murase K, Hanada S, Morokawa N, Kurosaki A, Fujii T, Hasegawa E, Takaya H, Takai D: Myeloperoxidase anti-neutrophil cytoplasmic antibody-associated vasculitis with a unique imaging presentation of organizing pneumonia: A case report. Respir Med Case Rep. 31:101294,2020
Kadota T*, Yoshioka Y, Fujita Y, Araya J, Minagawa S, Hara H, Miyamoto A,Suzuki S, Fujimori S, Kohno T, Fujii T, Kishi K, Kuwano K, Ochiya T: Extracellular vesicles from fibroblasts induce epithelial-cell senescence in pulmonary fibrosis. Am J Respir Cell Mol Biol. 63(5):623-636,2020
*National Cancer Center Research Institute
Yotsumoto T*, Maemura K, Watanabe K, Amano Y, Matsumoto Y, Zokumasu K, Ando T, Kawakami M, Kage H, Nakajima J, Yatomi Y, Nagase T, Takai D: NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer. Oncotarget, 29;11(39):3590-3600,2020
*The University of Tokyo Graduate School of Medicine
Nakashima S, Miyamoto A, Takahashi Y, Nakahama H, Moriguchi S, Murase K, Morokawa N, Takai D: Mendelson's syndrome complicated by bacterial aspiration pneumonia triggered by right putamen bleeding: A case report. Respir Med Case 33:101466,2021 doi: 10.1016/j.rmcr.2021.101466.
Komatsu M*, Yamamoto H, Matsui S, Terasaki Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A, Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki Y, Yoshizawa A, Takemura T, Kawabata Y, OguraT and the Tokyo Diffuse Lung Disease Study Group: Clinical characteristics of immunoglobulin G4-positive interstitial pneumonia. ERJ Open Res 2021; 7: 00317-2021
* First Dept of Internal Medicine, Shinshu University School of Medicine
Hanada S, Takata M, Morozumi M, Iwata S, Fujishima S, Ubukata K; Invasive Pneumococcal Diseases Surveillance Study Group: Multiple comorbidities increase the risk of death from invasive pneumococcal disease under the age of 65 years. J Infect Chemother. 27:1311-1318、2021
doi: 10.1016/j.jiac.2021.04.018. Epub 2021 May 4.
Komatsu M*, Yamamoto H, Uehara T, Kobayashi Y, Hozumi H, Fujisawa T, Miyamoto A, Kishaba T, Kunishima F, Okamoto M, Kitamura H, Iwasawa T, Matsushita S, Terasaki Y, Kunugi S, Ushiki A, Yasuo M, Suda T, Hanaoka M:Prognostic implication of IgG4 and IgG1-positive cell infiltration in the lung in patients with idiopathic interstitial pneumonia. Sci Rep. 2022 Jun 3;12(1):9303. doi: 10.1038/s41598-022-13333-8. PMID: 35661786 Free PMC article.
*First Department of Internal Medicine, Shinshu University School of Medicine
Murakami T*, Iijima Y, Ando T, Ejima M, Shirai T, Furusawa H, Okamoto T, Tateishi T, Tamaoka M, Miyazaki Y: Successful diagnosis of humidifier lung by individual provocation test to a responsible environment, a case report. Respir Med Case Rep. 2022 Mar 22;37:101639.
*Department of Respiratory Medicine, Tokyo Medical and Dental University
Ozawa S, Hanada S, Uruga H, Ito H, Nakahama H, Ishikawa N, Moriguchi S, Murase K, Miyamoto A, Hayashi N, Takai D: Disseminated cryptococcosis in a renal transplant recipient. Respirol Case Rep. 2022 Jul 31;10(9):e01011.
doi:10.1002/rcr2.1011. PMID: 35923712; PMCID: PMC9339528. 2022 Jul 31
Nakahama H, Hanada S, Takada K, Ishikawa N, Hirata N, Moriguchi S, Murase K, Miyamoto A, Fujii T, Ubukata K, Kishi K, Takai D, Tamaoka M: Obstructive pneumonia caused by Gordonia bronchialis with a bronchial foreign body. Int J Infect Dis. 2022 Nov; 124:157-158
doi: 10.1016/j.ijid.2022.09.028. Epub 2022 Sep 21. PMID: 36152956.
Aoyama Y, Miyamoto A, Fujii T, Fujimori S, Tamaoka M, Takai D: Primary bronchial schwannoma: A case report. Medicine (Baltimore). 2022 Oct 7; 101(40):e31062. 2022
doi: 10.1097/MD.0000000000031062. PMID: 36221358; PMCID:PMC9542747.
Komatsu M*, Yamamoto H, Matsui S, Terasaki Y, Hebisawa A, Iwasawa T, Johkoh T, Baba T, Miyamoto A, Handa T, Tomii K, Waseda Y, Bando M, Ishii H, Miyazaki Y, Yoshizawa A, Takemura T, Kawabata Y, Hanaoka M, Ogura T; Tokyo Diffuse Lung Disease Study Group: Respiratory lesions in IgG4-related disease: classification using 2019 American College of Rheumatology/European League Against Rheumatism criteria. ERJ Open Res. 2022 Sep 12;8(3):00120-2022.
doi:10.1183/23120541.00120-2022. PMID: 36105152; PMCID: PMC9465005.
*First Department of Internal Medicine, Shinshu University School of Medicine
Mitsumura T*, Okamoto T, Tosaka M, Yamana T, Shimada S, Iijima Y, Sakakibara R, Shibata S, Honda T, Shirai T, Ishizuka M, Aiboshi J, Furusawa H, Tateishi T, Tamaoka M, Shigemitsu H, Arai H, Otomo Y, Tohda S, Anzai T, Takahashi K, Yasuda S, Miyazaki Y: Association of SARS-CoV-2 RNA Copy Number with the COVID-19 Mortality Rate and Its Effect on the Predictive Performance of Mortality in Severe Cases. Jpn J Infect Dis. 2022 Sep 22;75(5):504-510.
*Department of Respiratory Medicine, Tokyo Medical and Dental University
Okuda R*, Ogura T, Hisata S, Baba T, Kondoh Y, Suda T, Johkoh T, Iwasawa T, Tomioka H, Bando M, Azuma A, Inoue Y, Arai T, Nakamura Y, Miyamoto A, Miyazaki Y, Chiba H, Ishii H, Hamada N, Terasaki Y, Kuwahira I, Sato S, Kato S, Suzuki T, Sakamoto S, Nishioka Y, Hattori N, Hashimoto N, Morita S, Ichihara N, Miyata H, Hagiwara K, Nukiwa T, Kobayashi K :Design and rationale of the Japanese Idiopathic Interstitial Pneumonias (JIPS) Registry. Respir Investig. 2023 Jan;61(1):95-102. doi: 10.1016/j.resinv.2022.08.009. Epub 2022 Nov 15. PMID:36580379.
*Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center
Miyamoto A, Michimae H, Nakahara Y, Akagawa S, Nakagawa K, Minegishi Y, Ogura T, Hontsu S, Date H, Takahashi K, Homma S, Kishi K: Chemotherapy versus best supportive care in advanced lung cancer and idiopathic interstitial pneumonias: A retrospective multi-centre cohort study.; Investigators Group for Lung Cancer and IIP. Respir Investig. 2022 Dec 7:S2212-5345(22)00151-4. doi: 10.1016/j.resinv.2022.10.009.
PMID: 36496345